TCGA-THCA · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | IGSF1 | 12.79 | 4.39 | 51.6 | 5.60 | 0.004 | 6.7e-01 ↓ | — |
| 2 | ARHGAP36 | 9.20 | 7.23 | 88.8 | 7.84 | 0.000 | 9.6e-01 ↓ | — |
| 3 | PC | 8.81 | 1.39 | 30.6 | 1.59 | 0.006 | 1.8e-01 ↓ | — |
| 4 | ZCCHC12 | 8.23 | 6.62 | 53.7 | 8.57 | 0.000 | 1.0e-01 ↓ | — |
| 5 | GABRB2 | 7.85 | 4.27 | 153.3 | 4.31 | 0.000 | 4.3e-02 ↑worse | — |
| 6 | TMEM215 | 7.50 | 4.01 | 76.7 | 4.37 | 0.000 | 4.8e-02 ↑worse | — |
| 7 | SRL | 6.89 | 1.32 | 15.4 | 2.41 | 0.000 | 3.1e-03 ↑worse | — |
| 8 | DCSTAMP | 6.79 | 5.26 | 46.8 | 7.26 | 0.000 | 8.2e-01 ↓ | — |
| 9 | SFTPA1 | 6.78 | 6.16 | 38.5 | 6.00 | 0.000 | 6.3e-01 ↓ | — |
| 10 | LRRK2 | 6.54 | 3.69 | 58.6 | 3.44 | 0.000 | 4.9e-02 ↑worse | — |
| 11 | SLC34A2 | 6.37 | 5.26 | 45.8 | 6.23 | 0.000 | 6.3e-02 ↓ | Act |
| 12 | PLK2 | 6.32 | 1.08 | 17.2 | -0.35 | 0.004 | 6.4e-01 ↑worse | — |
| 13 | ABR | 6.29 | 1.28 | 32.2 | 0.57 | 0.004 | 4.8e-01 ↓ | — |
| 14 | FN1 | 5.99 | 5.44 | 56.7 | 5.77 | 0.000 | 7.8e-01 ↓ | — |
| 15 | CITED1 | 5.84 | 2.84 | 91.5 | 1.09 | 0.000 | 1.2e-02 ↑worse | — |
| 16 | SLC22A31 | 5.81 | 5.51 | 135.4 | 5.36 | 0.000 | 8.2e-01 ↓ | — |
| 17 | KLHDC8A | 5.76 | 4.39 | 62.6 | 4.92 | 0.000 | 3.5e-01 ↑worse | — |
| 18 | INF2 | 5.73 | 1.51 | 53.4 | 0.05 | 0.004 | 1.4e-01 ↓ | — |
| 19 | PCSK1N | 5.71 | 4.33 | 48.2 | 4.41 | 0.000 | 2.7e-01 ↑worse | — |
| 20 | NAT8L | 5.65 | 2.68 | 31.0 | 3.35 | 0.000 | 4.2e-02 ↑worse | — |
| 21 | SERPINA1 | 5.21 | 4.50 | 60.8 | 6.42 | 0.000 | 3.8e-01 ↓ | — |
| 22 | PRR15 | 5.08 | 5.39 | 62.8 | 6.34 | 0.000 | 2.8e-02 ↓ | — |
| 23 | NMU | 5.08 | 4.46 | 37.2 | 5.56 | 0.000 | 9.1e-01 ↑worse | — |
| 24 | TMPRSS6 | 4.99 | 5.06 | 103.9 | 5.21 | 0.000 | 3.9e-01 ↓ | — |
| 25 | DPP4 | 4.86 | 3.87 | 73.9 | 3.83 | 0.000 | 2.7e-01 ↑worse | — |
| 26 | SLIT1 | 4.80 | 4.57 | 82.2 | 4.91 | 0.000 | 8.9e-01 ↑worse | — |
| 27 | SHROOM4 | 4.78 | 2.37 | 45.3 | 1.77 | 0.000 | 2.9e-02 ↑worse | — |
| 28 | CBLN1 | 4.74 | 3.30 | 53.1 | 2.88 | 0.000 | 1.1e-01 ↑worse | — |
| 29 | CST2 | 4.73 | 4.65 | 54.5 | 5.02 | 0.000 | 8.4e-01 ↓ | — |
| 30 | CHI3L1 | 4.71 | 4.60 | 26.3 | 5.09 | 0.000 | 8.0e-01 ↓ | — |
| 31 | B3GNT3 | 4.50 | 4.77 | 69.8 | 5.40 | 0.000 | 1.6e-01 ↓ | — |
| 32 | ECM1 | 4.44 | 4.55 | 62.5 | 3.32 | 0.000 | 5.1e-01 ↑worse | — |
| 33 | KLK7 | 4.43 | 4.99 | 64.7 | 5.68 | 0.000 | 4.5e-02 ↓ | — |
| 34 | CLDN16 | 4.37 | 4.70 | 56.1 | 6.37 | 0.000 | 2.6e-02 ↓ | — |
| 35 | ITGA7 | 4.34 | 1.03 | 18.0 | -1.68 | 0.004 | 2.5e-01 ↓ | — |
| 36 | TACSTD2 | 4.33 | 4.01 | 29.9 | 6.49 | 0.000 | 1.2e-01 ↓ | — |
| 37 | PDZK1IP1 | 4.32 | 3.94 | 31.9 | 5.86 | 0.000 | 4.4e-01 ↓ | — |
| 38 | KLK11 | 4.31 | 4.65 | 65.5 | 4.79 | 0.000 | 3.9e-01 ↓ | — |
| 39 | RXRG | 4.30 | 5.01 | 67.1 | 5.66 | 0.000 | 3.2e-02 ↓ | — |
| 40 | LAMB3 | 4.19 | 4.21 | 53.1 | 5.72 | 0.000 | 1.8e-01 ↓ | — |
| 41 | SFTPB | 4.16 | 4.69 | 20.7 | 4.52 | 0.000 | 3.8e-01 ↓ | — |
| 42 | SYT12 | 4.14 | 4.48 | 93.2 | 4.72 | 0.000 | 4.5e-01 ↓ | — |
| 43 | ICAM5 | 4.13 | 3.01 | 59.0 | 2.31 | 0.000 | 1.1e-01 ↑worse | — |
| 44 | LCN2 | 4.12 | 4.39 | 40.9 | 4.85 | 0.000 | 4.3e-01 ↓ | — |
| 45 | LIPH | 4.10 | 4.84 | 76.8 | 5.56 | 0.000 | 3.5e-02 ↓ | — |
| 46 | TMPRSS4 | 3.82 | 4.25 | 98.5 | 4.55 | 0.000 | 4.8e-01 ↓ | — |
| 47 | KLK10 | 3.80 | 4.71 | 85.3 | 5.17 | 0.000 | 4.4e-02 ↓ | — |
| 48 | RNU6ATAC18P | 3.80 | 1.38 | 10.2 | 3.01 | 0.000 | 5.5e-02 ↑worse | — |
| 49 | CD177 | 3.77 | 3.40 | 15.6 | 3.35 | 0.000 | 3.5e-01 ↑worse | — |
| 50 | KRT17 | 3.75 | 4.01 | 21.1 | 4.47 | 0.000 | 8.5e-01 ↓ | — |