TCGA-LUSC · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | COL11A1 | 17.16 | 4.35 | 72.9 | 4.80 | 0.204 | 9.9e-01 ↓ | — |
| 2 | CDKN2A | 16.14 | 3.69 | 66.2 | 4.00 | 0.137 | 9.6e-01 ↓ | Act |
| 3 | CNTNAP2 | 14.73 | 3.38 | 96.9 | 3.60 | 0.187 | 2.2e-01 ↓ | — |
| 4 | PTPRZ1 | 12.55 | 4.16 | 67.5 | 3.94 | 0.069 | 1.1e-01 ↓ | — |
| 5 | MUC4 | 11.49 | 1.76 | 5.2 | 2.60 | 0.085 | 7.2e-01 ↑worse | — |
| 6 | KRT6A | 10.46 | 8.24 | 48.5 | 10.40 | 0.000 | 7.9e-01 ↓ | — |
| 7 | KEAP1 | 10.34 | 1.07 | 37.8 | 1.74 | 0.081 | 1.9e-01 ↓ | Act |
| 8 | S100A7 | 10.24 | 7.81 | 58.5 | 8.88 | 0.000 | 4.7e-01 ↑worse | — |
| 9 | KIF1A | 10.22 | 3.03 | 50.4 | 2.91 | 0.044 | 5.1e-01 ↓ | — |
| 10 | KRT16 | 9.85 | 7.65 | 55.2 | 9.63 | 0.000 | 8.1e-01 ↑worse | — |
| 11 | KRT14 | 9.69 | 8.25 | 47.0 | 9.13 | 0.000 | 7.9e-01 ↓ | — |
| 12 | MMP1 | 9.54 | 5.55 | 36.1 | 6.76 | 0.000 | 6.5e-02 ↑worse | — |
| 13 | KRT5 | 9.21 | 7.34 | 44.3 | 9.93 | 0.000 | 5.0e-01 ↓ | — |
| 14 | BRCA1 | 9.11 | 1.73 | 42.5 | 2.04 | 0.042 | 1.4e-01 ↓ | Act |
| 15 | AKR1B10 | 9.09 | 7.73 | 56.0 | 9.28 | 0.000 | 4.4e-01 ↓ | — |
| 16 | SPRR1B | 9.00 | 7.40 | 51.2 | 9.29 | 0.000 | 7.1e-01 ↓ | — |
| 17 | ELMO3 | 8.89 | 1.12 | 25.9 | 1.48 | 0.000 | 4.7e-04 ↑worse | — |
| 18 | SLC2A1 | 8.81 | 5.67 | 77.7 | 5.49 | 0.000 | 6.8e-02 ↑worse | — |
| 19 | GABRP | 8.70 | 3.04 | 17.4 | 3.91 | 0.000 | 6.2e-03 ↑worse | — |
| 20 | VCAN | 8.62 | 1.02 | 5.3 | 0.22 | 0.079 | 7.1e-01 ↓ | — |
| 21 | KRT6B | 8.62 | 7.50 | 69.8 | 8.87 | 0.000 | 4.1e-01 ↓ | — |
| 22 | KRT17 | 8.44 | 6.68 | 41.9 | 8.84 | 0.000 | 8.5e-01 ↑worse | — |
| 23 | LY6D | 8.35 | 6.55 | 70.2 | 6.80 | 0.000 | 3.2e-01 ↑worse | — |
| 24 | THBS2 | 8.35 | 1.94 | 12.6 | 0.80 | 0.052 | 4.0e-01 ↓ | — |
| 25 | SPRR1A | 8.25 | 6.91 | 40.9 | 9.20 | 0.000 | 3.6e-01 ↓ | — |
| 26 | MMP10 | 7.94 | 6.38 | 48.2 | 7.59 | 0.000 | 5.7e-01 ↑worse | — |
| 27 | MMP13 | 7.90 | 5.98 | 61.8 | 6.76 | 0.000 | 3.1e-01 ↑worse | — |
| 28 | FAM83A | 7.80 | 5.01 | 107.3 | 5.50 | 0.000 | 9.6e-02 ↑worse | — |
| 29 | GPX2 | 7.65 | 6.75 | 61.8 | 8.10 | 0.000 | 6.1e-01 ↓ | — |
| 30 | SPRR2A | 7.45 | 7.13 | 53.1 | 8.77 | 0.000 | 5.6e-02 ↓ | — |
| 31 | DSG3 | 7.40 | 7.13 | 110.8 | 7.88 | 0.000 | 2.0e-01 ↓ | — |
| 32 | MYEOV | 7.36 | 3.39 | 70.5 | 3.38 | 0.000 | 4.2e-02 ↑worse | Act |
| 33 | CALML5 | 7.30 | 6.51 | 71.6 | 6.37 | 0.000 | 5.8e-01 ↑worse | — |
| 34 | GJB6 | 7.29 | 6.56 | 172.4 | 6.67 | 0.000 | 6.9e-01 ↑worse | — |
| 35 | S100A2 | 7.28 | 6.74 | 64.5 | 8.42 | 0.000 | 1.5e-01 ↓ | — |
| 36 | GJB2 | 7.27 | 6.05 | 57.6 | 7.72 | 0.000 | 8.1e-01 ↑worse | — |
| 37 | NTS | 7.25 | 6.32 | 25.5 | 8.88 | 0.000 | 1.7e-01 ↓ | — |
| 38 | NPTX2 | 7.22 | 3.32 | 8.2 | 4.25 | 0.000 | 2.7e-02 ↑worse | — |
| 39 | SPP1 | 7.13 | 4.54 | 26.5 | 6.68 | 0.000 | 2.0e-01 ↑worse | — |
| 40 | SPRR3 | 7.13 | 7.00 | 50.9 | 7.38 | 0.000 | 2.9e-01 ↓ | — |
| 41 | PKP3 | 7.09 | 2.41 | 41.9 | 2.89 | 0.000 | 8.6e-03 ↑worse | — |
| 42 | KRT13 | 6.94 | 7.21 | 67.9 | 6.64 | 0.000 | 3.6e-01 ↓ | — |
| 43 | SPRR2D | 6.94 | 6.43 | 56.3 | 7.72 | 0.000 | 3.7e-01 ↓ | — |
| 44 | BARX1 | 6.83 | 4.62 | 110.2 | 4.64 | 0.000 | 1.0e-01 ↑worse | — |
| 45 | RHOV | 6.76 | 4.22 | 32.2 | 5.73 | 0.000 | 1.4e-01 ↑worse | — |
| 46 | SERPINB5 | 6.70 | 6.34 | 70.9 | 7.41 | 0.000 | 4.0e-01 ↓ | — |
| 47 | EIF4G1 | 6.64 | 1.38 | 26.9 | 1.33 | 0.028 | 6.1e-01 ↓ | — |
| 48 | SPRR2E | 6.62 | 6.15 | 41.9 | 7.35 | 0.000 | 5.5e-01 ↓ | — |
| 49 | FDCSP | 6.62 | 4.71 | 8.1 | 9.12 | 0.000 | 8.8e-01 ↓ | — |
| 50 | OLFM4 | 6.61 | 3.92 | 37.3 | 2.60 | 0.000 | 3.0e-02 ↑worse | — |