TCGA-LUSC · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | COL11A1 | 17.15 | 4.34 | 72.9 | 4.79 | 0.204 | 9.9e-01 ↓ | — |
| 2 | CDKN2A | 16.13 | 3.69 | 66.3 | 4.00 | 0.137 | 9.6e-01 ↓ | Act |
| 3 | CNTNAP2 | 14.72 | 3.39 | 96.8 | 3.60 | 0.187 | 2.2e-01 ↓ | — |
| 4 | PTPRZ1 | 12.53 | 4.16 | 67.5 | 3.94 | 0.069 | 1.1e-01 ↓ | — |
| 5 | MUC4 | 11.48 | 1.76 | 5.3 | 2.61 | 0.085 | 7.2e-01 ↑worse | — |
| 6 | KRT6A | 10.47 | 8.24 | 48.5 | 10.40 | 0.000 | 7.9e-01 ↓ | — |
| 7 | KEAP1 | 10.36 | 1.07 | 37.8 | 1.74 | 0.081 | 2.1e-01 ↓ | Act |
| 8 | S100A7 | 10.25 | 7.82 | 58.6 | 8.88 | 0.000 | 4.7e-01 ↑worse | — |
| 9 | KIF1A | 10.20 | 3.03 | 50.4 | 2.90 | 0.044 | 5.1e-01 ↓ | — |
| 10 | KRT16 | 9.86 | 7.65 | 55.2 | 9.63 | 0.000 | 8.1e-01 ↑worse | — |
| 11 | KRT14 | 9.70 | 8.25 | 47.0 | 9.13 | 0.000 | 7.9e-01 ↓ | — |
| 12 | MMP1 | 9.54 | 5.55 | 36.1 | 6.76 | 0.000 | 6.6e-02 ↑worse | — |
| 13 | BRCA1 | 9.24 | 1.72 | 42.4 | 2.03 | 0.042 | 2.1e-01 ↓ | Act |
| 14 | KRT5 | 9.16 | 7.35 | 44.3 | 9.94 | 0.000 | 4.3e-01 ↓ | — |
| 15 | AKR1B10 | 9.10 | 7.72 | 56.0 | 9.28 | 0.000 | 4.4e-01 ↓ | — |
| 16 | SPRR1B | 9.03 | 7.41 | 51.3 | 9.30 | 0.000 | 7.1e-01 ↓ | — |
| 17 | ELMO3 | 8.90 | 1.12 | 25.9 | 1.48 | 0.000 | 4.7e-04 ↑worse | — |
| 18 | SLC2A1 | 8.82 | 5.67 | 77.6 | 5.49 | 0.000 | 6.8e-02 ↑worse | — |
| 19 | LY6D | 8.69 | 6.56 | 70.4 | 6.81 | 0.000 | 2.5e-01 ↑worse | — |
| 20 | KRT6B | 8.62 | 7.50 | 69.8 | 8.87 | 0.000 | 4.1e-01 ↓ | — |
| 21 | VCAN | 8.61 | 1.01 | 5.2 | 0.21 | 0.079 | 7.7e-01 ↓ | — |
| 22 | KRT17 | 8.45 | 6.68 | 41.9 | 8.84 | 0.000 | 8.5e-01 ↑worse | — |
| 23 | SPRR1A | 8.33 | 6.92 | 41.0 | 9.21 | 0.000 | 4.2e-01 ↓ | — |
| 24 | THBS2 | 8.29 | 1.94 | 12.5 | 0.80 | 0.052 | 3.7e-01 ↓ | — |
| 25 | FAM83A | 8.28 | 5.01 | 107.5 | 5.50 | 0.000 | 6.7e-02 ↑worse | — |
| 26 | GABRP | 8.21 | 3.04 | 17.5 | 3.92 | 0.000 | 9.0e-03 ↑worse | — |
| 27 | MMP13 | 8.07 | 5.98 | 61.7 | 6.76 | 0.000 | 2.7e-01 ↑worse | — |
| 28 | MMP10 | 7.94 | 6.38 | 48.2 | 7.59 | 0.000 | 5.7e-01 ↑worse | — |
| 29 | SPRR2A | 7.75 | 7.13 | 53.2 | 8.78 | 0.000 | 1.1e-01 ↓ | — |
| 30 | GPX2 | 7.65 | 6.75 | 61.7 | 8.10 | 0.000 | 6.1e-01 ↓ | — |
| 31 | DSG3 | 7.43 | 7.13 | 110.7 | 7.87 | 0.000 | 2.1e-01 ↓ | — |
| 32 | MYEOV | 7.36 | 3.39 | 70.4 | 3.38 | 0.000 | 4.2e-02 ↑worse | Act |
| 33 | CALML5 | 7.30 | 6.51 | 71.6 | 6.38 | 0.000 | 5.8e-01 ↑worse | — |
| 34 | GJB6 | 7.30 | 6.56 | 172.4 | 6.67 | 0.000 | 6.9e-01 ↑worse | — |
| 35 | GJB2 | 7.28 | 6.06 | 57.6 | 7.72 | 0.000 | 8.1e-01 ↑worse | — |
| 36 | NTS | 7.25 | 6.32 | 25.5 | 8.88 | 0.000 | 1.7e-01 ↓ | — |
| 37 | NPTX2 | 7.23 | 3.32 | 8.3 | 4.25 | 0.000 | 2.7e-02 ↑worse | — |
| 38 | SPRR3 | 7.15 | 7.01 | 51.0 | 7.39 | 0.000 | 2.9e-01 ↓ | — |
| 39 | SPP1 | 7.13 | 4.53 | 26.5 | 6.68 | 0.000 | 2.0e-01 ↑worse | — |
| 40 | S100A2 | 7.13 | 6.74 | 64.6 | 8.42 | 0.000 | 1.0e-01 ↓ | — |
| 41 | BARX1 | 7.08 | 4.62 | 110.5 | 4.64 | 0.000 | 8.6e-02 ↑worse | — |
| 42 | PKP3 | 7.08 | 2.41 | 41.9 | 2.90 | 0.000 | 8.7e-03 ↑worse | — |
| 43 | KRT13 | 6.95 | 7.21 | 68.0 | 6.64 | 0.000 | 3.6e-01 ↓ | — |
| 44 | RHOV | 6.77 | 4.23 | 32.3 | 5.73 | 0.000 | 1.4e-01 ↑worse | — |
| 45 | SPRR2D | 6.75 | 6.43 | 56.4 | 7.72 | 0.000 | 2.3e-01 ↓ | — |
| 46 | EIF4G1 | 6.71 | 1.38 | 26.9 | 1.33 | 0.028 | 7.6e-01 ↓ | — |
| 47 | SERPINB5 | 6.70 | 6.34 | 70.9 | 7.41 | 0.000 | 4.0e-01 ↓ | — |
| 48 | DLG1 | 6.66 | 1.25 | 39.5 | 0.74 | 0.032 | 8.9e-01 ↓ | — |
| 49 | FDCSP | 6.65 | 4.71 | 8.1 | 9.12 | 0.000 | 9.3e-01 ↓ | — |
| 50 | SPRR2E | 6.55 | 6.15 | 42.1 | 7.35 | 0.000 | 4.5e-01 ↓ | — |