TCGA-LUAD · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | CPS1 | 14.71 | 5.42 | 23.3 | 4.79 | 0.142 | 1.1e-01 ↑worse | — |
| 2 | COL11A1 | 13.60 | 4.34 | 86.8 | 4.63 | 0.272 | 1.3e-02 ↓ | — |
| 3 | MUC16 | 13.21 | 1.84 | 17.0 | 2.45 | 0.815 | 7.2e-02 ↑worse | — |
| 4 | AHNAK2 | 11.80 | 1.92 | 18.8 | 2.61 | 0.178 | 8.0e-04 ↑worse | — |
| 5 | TFF1 | 10.59 | 7.77 | 46.7 | 8.37 | 0.000 | 3.8e-02 ↑worse | — |
| 6 | CDKN2A | 9.88 | 2.92 | 51.3 | 3.19 | 0.053 | 2.8e-01 ↑worse | Act |
| 7 | TFF2 | 9.29 | 7.35 | 19.2 | 7.43 | 0.000 | 7.6e-02 ↑worse | — |
| 8 | FGB | 8.88 | 7.10 | 37.5 | 7.06 | 0.000 | 5.7e-02 ↑worse | — |
| 9 | CALCA | 8.62 | 7.42 | 8.6 | 7.72 | 0.000 | 8.4e-01 ↓ | — |
| 10 | FAM83A | 8.54 | 5.52 | 132.5 | 6.13 | 0.000 | 2.3e-04 ↑worse | — |
| 11 | COL6A3 | 8.40 | 1.19 | 10.5 | 0.30 | 0.162 | 3.6e-01 ↑worse | LoF |
| 12 | VCAN | 8.31 | 1.61 | 16.4 | 0.32 | 0.178 | 9.4e-02 ↑worse | — |
| 13 | SPINK1 | 8.13 | 6.44 | 41.0 | 8.15 | 0.000 | 5.2e-01 ↑worse | — |
| 14 | KIF1A | 7.97 | 2.86 | 25.6 | 2.84 | 0.056 | 3.6e-01 ↓ | — |
| 15 | BPIFA1 | 7.65 | 5.18 | 7.2 | 9.53 | 0.000 | 6.0e-01 ↑worse | — |
| 16 | PAEP | 7.60 | 6.55 | 42.5 | 7.49 | 0.000 | 9.4e-01 ↑worse | — |
| 17 | ADAMTS12 | 7.49 | 1.50 | 24.2 | 0.83 | 0.173 | 2.5e-01 ↓ | — |
| 18 | SPRR1B | 7.40 | 4.80 | 25.3 | 5.05 | 0.000 | 9.2e-05 ↑worse | — |
| 19 | BRCA1 | 7.37 | 1.19 | 37.5 | 1.45 | 0.038 | 1.1e-02 ↑worse | Act |
| 20 | AKR1B10 | 7.14 | 6.44 | 35.7 | 7.09 | 0.000 | 5.3e-01 ↓ | — |
| 21 | KRT6A | 7.06 | 5.01 | 18.3 | 5.20 | 0.000 | 5.9e-04 ↑worse | — |
| 22 | GPX2 | 7.05 | 5.64 | 36.6 | 6.59 | 0.000 | 5.5e-02 ↑worse | — |
| 23 | THBS2 | 6.97 | 2.71 | 28.0 | 0.60 | 0.053 | 1.6e-01 ↑worse | — |
| 24 | TCN1 | 6.66 | 5.29 | 39.1 | 5.00 | 0.000 | 3.0e-03 ↑worse | — |
| 25 | KRT81 | 6.52 | 4.77 | 29.5 | 5.25 | 0.000 | 1.5e-03 ↑worse | — |
| 26 | CYP24A1 | 6.47 | 5.61 | 78.6 | 6.31 | 0.000 | 1.6e-01 ↑worse | — |
| 27 | S100P | 6.10 | 5.03 | 33.8 | 5.97 | 0.000 | 4.1e-02 ↑worse | — |
| 28 | CST1 | 6.05 | 5.28 | 63.6 | 6.31 | 0.000 | 1.9e-01 ↑worse | — |
| 29 | CA9 | 6.01 | 4.48 | 50.6 | 5.06 | 0.000 | 1.9e-03 ↑worse | — |
| 30 | MYEOV | 5.89 | 4.03 | 86.7 | 4.01 | 0.000 | 3.0e-03 ↑worse | Act |
| 31 | REG4 | 5.73 | 5.85 | 8.1 | 5.90 | 0.000 | 4.8e-01 ↓ | — |
| 32 | MUC5B | 5.69 | 3.84 | 13.0 | 6.45 | 0.000 | 9.3e-03 ↑worse | — |
| 33 | SST | 5.68 | 5.64 | 6.5 | 6.04 | 0.000 | — | — |
| 34 | SLC2A1 | 5.62 | 3.41 | 58.6 | 2.94 | 0.000 | 4.6e-06 ↑worse | — |
| 35 | TOP2A | 5.61 | 3.66 | 68.4 | 4.36 | 0.000 | 4.2e-03 ↑worse | Act |
| 36 | ALB | 5.58 | 6.33 | 12.7 | 4.75 | 0.000 | 9.7e-01 ↑worse | — |
| 37 | SPINK4 | 5.55 | 5.64 | 25.5 | 5.86 | 0.000 | 9.8e-01 ↓ | — |
| 38 | RHOV | 5.54 | 3.34 | 24.7 | 4.81 | 0.000 | 1.5e-04 ↑worse | — |
| 39 | TM4SF4 | 5.51 | 5.02 | 14.1 | 6.00 | 0.000 | 2.3e-01 ↑worse | — |
| 40 | PCSK1 | 5.50 | 4.58 | 15.4 | 4.67 | 0.000 | 5.3e-03 ↑worse | — |
| 41 | CEACAM5 | 5.48 | 4.83 | 24.3 | 7.08 | 0.000 | 8.2e-01 ↓ | — |
| 42 | CRABP2 | 5.46 | 5.51 | 63.5 | 6.25 | 0.000 | 1.2e-01 ↓ | — |
| 43 | KRT16 | 5.43 | 3.58 | 30.1 | 4.12 | 0.000 | 1.2e-04 ↑worse | — |
| 44 | ANLN | 5.42 | 3.29 | 83.3 | 3.72 | 0.000 | 2.4e-05 ↑worse | — |
| 45 | MMP1 | 5.40 | 4.86 | 32.1 | 5.59 | 0.000 | 9.1e-02 ↑worse | — |
| 46 | CT83 | 5.34 | 4.48 | 61.3 | 4.81 | 0.000 | 7.9e-03 ↑worse | — |
| 47 | KRT20 | 5.31 | 4.96 | 6.9 | 5.13 | 0.000 | 6.7e-02 ↑worse | — |
| 48 | GJB3 | 5.24 | 2.72 | 25.1 | 3.51 | 0.000 | 4.8e-06 ↑worse | — |
| 49 | TNS4 | 5.14 | 3.32 | 31.3 | 4.27 | 0.000 | 1.6e-04 ↑worse | — |
| 50 | MUC13 | 5.05 | 4.90 | 35.8 | 5.52 | 0.000 | 2.5e-01 ↑worse | — |