TCGA-LUAD · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | CPS1 | 15.79 | 5.39 | 22.9 | 4.76 | 0.142 | 5.9e-02 ↑worse | — |
| 2 | COL11A1 | 14.45 | 4.39 | 87.1 | 4.68 | 0.272 | 3.7e-03 ↓ | — |
| 3 | AHNAK2 | 12.91 | 1.93 | 18.6 | 2.62 | 0.178 | 8.8e-04 ↑worse | — |
| 4 | TFF1 | 11.21 | 7.83 | 45.5 | 8.42 | 0.000 | 9.8e-03 ↑worse | — |
| 5 | CDKN2A | 10.43 | 2.93 | 50.1 | 3.20 | 0.053 | 4.3e-01 ↑worse | Act |
| 6 | TFF2 | 9.47 | 7.65 | 18.9 | 7.73 | 0.000 | 1.8e-01 ↑worse | — |
| 7 | ADAMTS12 | 9.26 | 1.50 | 24.2 | 0.83 | 0.173 | 1.6e-01 ↑worse | — |
| 8 | COL6A3 | 9.23 | 1.20 | 10.7 | 0.31 | 0.162 | 4.8e-01 ↑worse | LoF |
| 9 | FGB | 8.89 | 7.11 | 37.3 | 7.07 | 0.000 | 6.1e-02 ↑worse | — |
| 10 | FAM83A | 8.78 | 5.54 | 132.4 | 6.14 | 0.000 | 2.3e-04 ↑worse | — |
| 11 | KIF1A | 8.75 | 2.94 | 26.0 | 2.92 | 0.056 | 3.3e-01 ↓ | — |
| 12 | CALCA | 8.72 | 7.43 | 8.9 | 7.73 | 0.000 | 6.9e-01 ↑worse | — |
| 13 | VCAN | 8.18 | 1.64 | 16.4 | 0.35 | 0.178 | 9.7e-02 ↓ | — |
| 14 | BRCA1 | 8.12 | 1.18 | 37.3 | 1.45 | 0.038 | 1.1e-02 ↑worse | Act |
| 15 | SPINK1 | 7.87 | 6.43 | 40.8 | 8.14 | 0.000 | 8.6e-01 ↑worse | — |
| 16 | THBS2 | 7.84 | 2.74 | 28.3 | 0.63 | 0.053 | 1.2e-01 ↑worse | — |
| 17 | PAEP | 7.57 | 6.56 | 42.3 | 7.50 | 0.000 | 9.0e-01 ↑worse | — |
| 18 | BPIFA1 | 7.35 | 5.13 | 6.7 | 9.48 | 0.000 | 9.1e-01 ↑worse | — |
| 19 | SPRR1B | 7.23 | 4.74 | 24.9 | 5.00 | 0.000 | 2.2e-04 ↑worse | — |
| 20 | GPX2 | 7.12 | 5.62 | 36.6 | 6.57 | 0.000 | 4.6e-02 ↑worse | — |
| 21 | AKR1B10 | 6.89 | 6.34 | 35.5 | 6.99 | 0.000 | 5.3e-01 ↓ | — |
| 22 | GJB2 | 6.89 | 4.08 | 59.7 | 4.98 | 0.000 | 8.3e-05 ↑worse | — |
| 23 | KRT6A | 6.78 | 5.08 | 18.3 | 5.27 | 0.000 | 2.8e-03 ↑worse | — |
| 24 | KRT81 | 6.44 | 4.79 | 29.5 | 5.26 | 0.000 | 3.0e-03 ↑worse | — |
| 25 | CA9 | 6.43 | 4.50 | 50.8 | 5.08 | 0.000 | 1.1e-03 ↑worse | — |
| 26 | TCN1 | 6.40 | 5.30 | 39.9 | 5.01 | 0.000 | 8.7e-03 ↑worse | — |
| 27 | CST1 | 6.13 | 5.42 | 64.0 | 6.46 | 0.000 | 2.9e-01 ↑worse | — |
| 28 | CYP24A1 | 6.13 | 5.59 | 77.8 | 6.29 | 0.000 | 3.4e-01 ↑worse | — |
| 29 | S100P | 6.06 | 5.03 | 33.4 | 5.96 | 0.000 | 5.2e-02 ↑worse | — |
| 30 | CT83 | 5.90 | 4.44 | 61.4 | 4.78 | 0.000 | 2.2e-03 ↑worse | — |
| 31 | MMP1 | 5.85 | 4.91 | 32.1 | 5.64 | 0.000 | 3.8e-02 ↑worse | — |
| 32 | PCSK1 | 5.82 | 4.62 | 15.5 | 4.70 | 0.000 | 3.7e-03 ↑worse | — |
| 33 | SPINK4 | 5.77 | 5.82 | 24.8 | 6.04 | 0.000 | 7.2e-01 ↓ | — |
| 34 | REG4 | 5.71 | 5.85 | 8.4 | 5.91 | 0.000 | 7.1e-01 ↓ | — |
| 35 | MYEOV | 5.59 | 4.04 | 85.3 | 4.02 | 0.000 | 1.0e-02 ↑worse | Act |
| 36 | SST | 5.58 | 5.62 | 6.2 | 6.02 | 0.000 | — | — |
| 37 | ALB | 5.55 | 6.33 | 13.2 | 4.75 | 0.000 | 8.7e-01 ↑worse | — |
| 38 | TM4SF4 | 5.55 | 5.16 | 15.1 | 6.14 | 0.000 | 3.9e-01 ↑worse | — |
| 39 | CIT | 5.55 | 1.87 | 18.1 | 1.59 | 0.027 | 5.3e-01 ↑worse | — |
| 40 | TOP2A | 5.54 | 3.67 | 68.7 | 4.36 | 0.000 | 7.5e-03 ↑worse | Act |
| 41 | SNORA73B | 5.54 | 5.77 | 16.2 | 5.09 | 0.000 | 3.5e-01 ↑worse | — |
| 42 | TNS4 | 5.50 | 3.32 | 31.0 | 4.27 | 0.000 | 1.2e-04 ↑worse | — |
| 43 | MUC5B | 5.47 | 3.80 | 12.4 | 6.41 | 0.000 | 1.8e-02 ↑worse | — |
| 44 | ANLN | 5.45 | 3.30 | 83.1 | 3.72 | 0.000 | 5.1e-05 ↑worse | — |
| 45 | KRT16 | 5.37 | 3.64 | 30.2 | 4.18 | 0.000 | 3.5e-04 ↑worse | — |
| 46 | CEACAM5 | 5.36 | 4.78 | 23.9 | 7.04 | 0.000 | 9.6e-01 ↓ | — |
| 47 | CRABP2 | 5.34 | 5.50 | 63.3 | 6.24 | 0.000 | 1.0e-01 ↓ | — |
| 48 | MUC13 | 5.30 | 4.99 | 36.1 | 5.61 | 0.000 | 1.9e-01 ↑worse | — |
| 49 | SLC2A1 | 5.27 | 3.42 | 58.6 | 2.94 | 0.000 | 3.0e-05 ↑worse | — |
| 50 | HOXB9 | 5.26 | 4.14 | 43.2 | 4.22 | 0.000 | 1.9e-03 ↑worse | — |