TCGA-LIHC · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | REG3A | 16.41 | 8.74 | 24.6 | 8.77 | 0.000 | 9.0e-01 ↑worse | — |
| 2 | AFP | 13.72 | 7.28 | 25.3 | 8.04 | 0.000 | 5.2e-01 ↑worse | — |
| 3 | GPC3 | 12.99 | 6.48 | 49.3 | 8.58 | 0.000 | 4.5e-01 ↑worse | — |
| 4 | SPP1 | 12.75 | 5.17 | 20.2 | 6.78 | 0.000 | 5.5e-05 ↑worse | — |
| 5 | FASN | 12.74 | 1.73 | 12.3 | 1.48 | 0.066 | 4.4e-02 ↑worse | — |
| 6 | PGC | 12.16 | 7.43 | 29.4 | 5.83 | 0.000 | 3.9e-01 ↑worse | — |
| 7 | S100P | 11.96 | 6.24 | 26.3 | 7.17 | 0.000 | 1.0e-01 ↑worse | — |
| 8 | REG1A | 11.33 | 7.34 | 24.6 | 5.03 | 0.000 | 4.0e-01 ↑worse | — |
| 9 | BAP1 | 11.28 | 1.15 | 26.2 | 0.73 | 0.050 | 5.8e-02 ↑worse | LoF |
| 10 | NQO1 | 10.33 | 5.13 | 31.5 | 6.52 | 0.000 | 1.7e-02 ↑worse | — |
| 11 | AKR1B10 | 10.28 | 4.08 | 15.5 | 8.07 | 0.000 | 8.3e-03 ↑worse | — |
| 12 | SMARCA4 | 10.03 | 1.60 | 41.4 | 0.74 | 0.029 | 6.3e-02 ↑worse | LoF |
| 13 | RUSC1 | 9.96 | 1.91 | 52.7 | 1.33 | 0.024 | 6.9e-03 ↑worse | — |
| 14 | PAEP | 9.77 | 4.91 | 17.8 | 4.94 | 0.000 | 7.9e-04 ↑worse | — |
| 15 | MAP2 | 9.72 | 1.62 | 20.2 | 2.04 | 0.029 | 1.2e-01 ↑worse | — |
| 16 | MUC13 | 9.68 | 5.31 | 30.1 | 6.65 | 0.000 | 2.8e-01 ↑worse | — |
| 17 | DLK1 | 9.66 | 6.05 | 8.0 | 6.38 | 0.000 | 1.5e-02 ↓ | — |
| 18 | CDC20 | 9.57 | 4.17 | 81.0 | 4.64 | 0.000 | 3.2e-05 ↑worse | — |
| 19 | ALDH3A1 | 9.25 | 5.33 | 17.1 | 6.28 | 0.000 | 4.1e-01 ↑worse | — |
| 20 | PEG10 | 9.01 | 4.91 | 19.2 | 6.10 | 0.000 | 8.7e-02 ↑worse | — |
| 21 | NSD2 | 8.98 | 1.48 | 54.3 | 0.95 | 0.019 | 1.6e-02 ↑worse | Act |
| 22 | SFN | 8.94 | 4.19 | 26.4 | 5.16 | 0.000 | 5.9e-04 ↑worse | — |
| 23 | CCL25 | 8.82 | 5.65 | 29.8 | 5.99 | 0.000 | 4.5e-02 ↓ | — |
| 24 | NOP56 | 8.72 | 1.59 | 28.1 | 1.13 | 0.016 | 8.0e-04 ↑worse | — |
| 25 | LCN2 | 8.65 | 5.12 | 24.6 | 6.03 | 0.000 | 4.8e-01 ↑worse | — |
| 26 | CST1 | 8.63 | 5.50 | 17.9 | 5.66 | 0.000 | 8.6e-01 ↓ | — |
| 27 | PABPC1 | 8.62 | 1.71 | 35.7 | 1.52 | 0.011 | 3.5e-03 ↑worse | Act |
| 28 | TOP2A | 8.59 | 3.80 | 71.4 | 4.31 | 0.000 | 1.1e-03 ↑worse | Act |
| 29 | FDCSP | 8.43 | 4.77 | 10.9 | 5.20 | 0.000 | 3.0e-02 ↑worse | — |
| 30 | LMNA | 8.29 | 1.57 | 23.1 | 2.38 | 0.013 | 8.7e-03 ↑worse | — |
| 31 | NACA | 8.24 | 1.05 | 29.2 | 0.96 | 0.019 | 2.0e-02 ↑worse | ambiguous |
| 32 | PTTG1 | 8.16 | 3.69 | 73.6 | 4.16 | 0.000 | 6.0e-05 ↑worse | — |
| 33 | KIFC1 | 8.07 | 3.46 | 92.7 | 3.86 | 0.000 | 1.5e-05 ↑worse | — |
| 34 | MDK | 7.95 | 4.31 | 34.7 | 6.36 | 0.000 | 2.2e-01 ↑worse | — |
| 35 | LAMB1 | 7.85 | 1.42 | 14.1 | 0.34 | 0.019 | 2.6e-03 ↑worse | — |
| 36 | COPA | 7.66 | 1.31 | 30.7 | 1.44 | 0.019 | 3.5e-02 ↑worse | — |
| 37 | MYBL2 | 7.64 | 4.14 | 90.3 | 4.47 | 0.000 | 3.2e-03 ↑worse | — |
| 38 | PAGE4 | 7.59 | 5.10 | 23.3 | 5.21 | 0.000 | 6.5e-01 ↓ | — |
| 39 | TSC2 | 7.57 | 1.12 | 31.7 | -0.85 | 0.032 | 3.7e-01 ↑worse | LoF |
| 40 | BAG6 | 7.54 | 1.18 | 36.3 | 1.31 | 0.019 | 2.0e-02 ↑worse | — |
| 41 | MAP1S | 7.49 | 1.08 | 20.2 | 1.41 | 0.021 | 6.4e-02 ↑worse | — |
| 42 | CCNB1 | 7.42 | 3.55 | 74.7 | 4.11 | 0.000 | 2.2e-04 ↑worse | — |
| 43 | BIRC5 | 7.39 | 3.70 | 86.0 | 3.70 | 0.000 | 1.7e-04 ↑worse | — |
| 44 | PTK2 | 7.38 | 1.35 | 37.6 | 1.67 | 0.016 | 3.7e-02 ↑worse | — |
| 45 | SPINK1 | 7.30 | 3.43 | 9.4 | 6.16 | 0.000 | 2.1e-02 ↑worse | — |
| 46 | MED24 | 7.28 | 1.28 | 38.4 | 0.79 | 0.021 | 6.3e-02 ↑worse | — |
| 47 | CHD4 | 7.27 | 1.01 | 27.4 | -1.65 | 0.021 | 1.9e-03 ↑worse | Act |
| 48 | DDR1 | 7.26 | 1.96 | 11.0 | 2.67 | 0.013 | 3.0e-01 ↓ | — |
| 49 | LINC01419 | 7.25 | 4.68 | 40.0 | 4.69 | 0.000 | 1.5e-01 ↑worse | — |
| 50 | ETV4 | 7.10 | 3.06 | 33.0 | 3.81 | 0.000 | 8.1e-04 ↑worse | Act |