TCGA-HNSC · 50 ranked genes · over-expressed in tumor, supported by survival / mutation / known-driver evidence
| # | Gene | Composite | Over-expr (log2FC)GDC tumor vs normal | −log10 pGDC | Tumor-specificity vs GTExGTEx healthy tissue | Mutation freqGDC SSM | Survival p (hi-expr)GDC clinical | Known driverintOGen |
|---|---|---|---|---|---|---|---|---|
| 1 | CDKN2A | 17.97 | 3.36 | 20.2 | 4.48 | 0.205 | 2.6e-01 ↓ | Act |
| 2 | COL11A1 | 15.55 | 3.76 | 30.6 | 4.05 | 0.123 | 5.1e-02 ↓ | — |
| 3 | FAT1 | 13.65 | 1.52 | 9.1 | 2.04 | 0.246 | 1.6e-01 ↓ | Act |
| 4 | MMP13 | 12.47 | 6.14 | 31.1 | 7.92 | 0.000 | 1.2e-01 ↑worse | — |
| 5 | FN1 | 11.20 | 3.41 | 15.2 | 3.20 | 0.036 | 5.8e-02 ↓ | — |
| 6 | PLEC | 10.43 | 1.17 | 10.8 | 2.07 | 0.146 | 1.0e-01 ↓ | — |
| 7 | DKK1 | 9.63 | 2.06 | 9.5 | 2.87 | 0.000 | 4.8e-08 ↑worse | — |
| 8 | CA9 | 9.53 | 5.15 | 51.0 | 5.96 | 0.000 | 1.1e-01 ↑worse | — |
| 9 | INHBA | 9.47 | 4.04 | 27.5 | 3.86 | 0.000 | 1.8e-04 ↑worse | — |
| 10 | MAGEA4 | 9.42 | 5.08 | 30.5 | 5.69 | 0.000 | 7.4e-02 ↑worse | — |
| 11 | MMP1 | 9.07 | 3.39 | 17.9 | 9.11 | 0.000 | 6.4e-02 ↑worse | — |
| 12 | VCAN | 9.03 | 1.98 | 9.8 | 2.04 | 0.047 | 4.3e-01 ↓ | — |
| 13 | LAMC2 | 8.49 | 3.97 | 22.9 | 5.76 | 0.000 | 1.3e-02 ↑worse | — |
| 14 | SERPINE1 | 8.10 | 3.29 | 16.3 | 5.25 | 0.000 | 1.5e-03 ↑worse | — |
| 15 | MAGEA6 | 8.09 | 4.78 | 39.1 | 5.12 | 0.000 | 1.7e-01 ↑worse | — |
| 16 | BRCA1 | 7.66 | 1.37 | 17.7 | 2.23 | 0.025 | 3.5e-01 ↓ | Act |
| 17 | MMP11 | 7.55 | 5.10 | 36.5 | 4.93 | 0.000 | 7.0e-01 ↓ | — |
| 18 | PLAU | 7.49 | 2.88 | 18.9 | 3.97 | 0.000 | 2.3e-04 ↑worse | — |
| 19 | MMP10 | 7.36 | 3.14 | 10.5 | 7.49 | 0.000 | 9.0e-02 ↑worse | — |
| 20 | GAST | 7.27 | 3.72 | 65.1 | 4.17 | 0.000 | 7.4e-03 ↑worse | — |
| 21 | MMP9 | 7.17 | 4.18 | 21.6 | 6.53 | 0.000 | 8.6e-01 ↓ | — |
| 22 | MMP12 | 7.10 | 3.99 | 21.9 | 6.49 | 0.000 | 6.2e-01 ↑worse | — |
| 23 | FLNA | 7.00 | 1.52 | 13.4 | 1.68 | 0.038 | 2.3e-02 ↓ | — |
| 24 | MAGEA3 | 6.99 | 4.68 | 29.2 | 5.27 | 0.000 | 3.7e-01 ↓ | — |
| 25 | ISG15 | 6.94 | 3.95 | 22.3 | 6.42 | 0.000 | 6.7e-01 ↑worse | — |
| 26 | PTPRZ1 | 6.92 | 1.05 | 4.7 | 2.73 | 0.030 | 7.8e-01 ↓ | — |
| 27 | CXCL11 | 6.90 | 3.63 | 13.6 | 6.29 | 0.000 | 2.2e-01 ↑worse | — |
| 28 | STAT1 | 6.87 | 1.79 | 13.8 | 2.58 | 0.019 | 7.7e-01 ↓ | — |
| 29 | STC2 | 6.75 | 2.80 | 26.9 | 3.07 | 0.000 | 2.2e-04 ↑worse | — |
| 30 | TGFBI | 6.61 | 3.67 | 25.9 | 2.94 | 0.000 | 4.2e-03 ↑worse | — |
| 31 | SEC61G | 6.35 | 1.73 | 24.8 | 1.19 | 0.000 | 1.1e-06 ↑worse | — |
| 32 | CSF2 | 6.34 | 3.43 | 37.6 | 4.02 | 0.000 | 1.5e-02 ↑worse | — |
| 33 | PNCK | 6.31 | 2.27 | 30.6 | 2.43 | 0.011 | 6.2e-01 ↓ | — |
| 34 | INF2 | 6.30 | 1.27 | 20.1 | 0.66 | 0.013 | 7.8e-03 ↑worse | — |
| 35 | FSCN1 | 6.15 | 2.13 | 15.2 | 4.46 | 0.000 | 5.4e-04 ↑worse | — |
| 36 | CXCL10 | 6.14 | 3.26 | 11.1 | 7.62 | 0.000 | 1.4e-01 ↓ | — |
| 37 | AMTN | 5.95 | 4.11 | 10.1 | 5.14 | 0.000 | 3.5e-01 ↓ | — |
| 38 | HMGA2 | 5.89 | 3.05 | 55.2 | 3.41 | 0.000 | 4.4e-03 ↑worse | — |
| 39 | ITGA5 | 5.86 | 2.71 | 21.4 | 1.77 | 0.000 | 1.5e-04 ↑worse | — |
| 40 | COL1A1 | 5.86 | 3.38 | 16.6 | 5.06 | 0.000 | 2.8e-01 ↓ | LoF |
| 41 | PTHLH | 5.76 | 3.75 | 21.9 | 5.10 | 0.000 | 5.8e-01 ↑worse | — |
| 42 | ULBP2 | 5.75 | 2.14 | 14.2 | 4.99 | 0.000 | 2.6e-03 ↑worse | — |
| 43 | COL10A1 | 5.75 | 4.45 | 53.3 | 3.97 | 0.000 | 4.8e-01 ↓ | — |
| 44 | LAMB1 | 5.59 | 1.75 | 17.6 | -0.07 | 0.025 | 6.7e-01 ↓ | — |
| 45 | PLEK2 | 5.58 | 2.32 | 16.4 | 4.20 | 0.000 | 2.2e-03 ↑worse | — |
| 46 | CCNA1 | 5.53 | 2.23 | 8.9 | 3.85 | 0.000 | 1.1e-03 ↑worse | — |
| 47 | IFI6 | 5.49 | 3.36 | 18.2 | 4.78 | 0.000 | 1.8e-01 ↑worse | — |
| 48 | CASC9 | 5.45 | 2.96 | 31.9 | 3.61 | 0.000 | 1.0e-02 ↑worse | — |
| 49 | RPL29P19 | 5.36 | 3.04 | 40.9 | 2.84 | 0.000 | 5.6e-03 ↑worse | — |
| 50 | ITGB1 | 5.20 | 1.16 | 8.5 | 0.17 | 0.030 | 3.8e-01 ↓ | — |